June 16, 2021

nootropics for anxiety and depression

Anxiety is a common problem now more than ever and more people are finding nootropics to be the solution.

Contrary to what most people think, nootropics aren’t just for memory or focus It’s an effective treatment for curing anxiety.

Obviously, anxiety is a complex problem that comes down to multiple factors such as Genetics, imbalanced hormones, mood regulation in the brain, stressful events, and other medical problems.

That being said using nootropics to help with managing anxiety can be a godsend that you’ve been looking for. Using nootropics and a few other supplements have been instrumental in helping with anxiety, if you haven’t tried it yet or haven’t heard nootropics that calm your nerves read on for a full guide to which nootropics are the best for eliminating anxiety.

How Anxiety Takes Hold

best nootropics for anxiety and depression

If you deal with anxiety on a daily basis you know it’s absolute hell to deal with. Living day to day with it is a challenge itself.

You might be wondering how you or your loved one got this way in the first place, there are many theories as to how they take root there are a few basic ways they form such as:

  • Past truama
  • Stressful events
  • Change in hormones

There are several other reasons but a lot of cases can be linked back to these reasons. It is important to get help and deal with anxiety to fully help get over it but using high-quality nootropics can provide a major edge in fighting it.

Thankfully the nootropics industry has come a long way in the past decade, companies make supplements designed to help regulate mood and calm your mind down to help with the symptoms of mild to severe anxiety.

Below is a list of the best nootropics I’ve found that really help put your general anxiety out of the picture, so if you’re ready to get rid of your anxiety for good then read on.

Best Nootropics For Fighting Anxiety

As I mentioned before, companies today make nootropics specifically formulated to destroy anxiety and there’s a lot of options to choose from when it comes down to it.

You’ll have to play around with certain supplements to see which one works specifically well with you and your brain chemistry, that being said this article is is here to help inform you which ones work the best.

A good nootropic for treating anxiety does a few things those include:

  • Support relaxation in the brain without feeling drowsy
  • Regulate Mood

With those in mind here are the actual nootropics.


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Phenibut is by far one of the most powerful compounds you can use for anxiety. In fact, It works really well for getting over social anxiety.

If you don’t know Phenibut was created in the 60s by Russian scientists to give to cosmonauts in case of an emergency. It’s a compound that is formulated to relax the user but still keep them in an alert problem-solving state. Nowadays it is used by students and entrepreneurs alike to take the edge off when

Being a GABA derivative, Phenibut crosses the blood-brain barrier for non-sedative effects while easing short-term acute anxiety making it effective for anyone with mild to severe anxiety.


The benefits of Phenibut lie in its ability to completely dissolve any stress and anxiety you may feel without impairing your ability to remain functional throughout the day. A lot of people like to pair it with coffee for an added energy boost, meaning you get the relaxing effects of phenibut and a nice energy boost from the coffee.

Some other benefits of using Phenibut Include:

  • Improved sleep quality
  • Significant reduction in anxiety
  • Improved mood
  • Better emotional intelligence
  • Energizes you
  • Helps you focus

If you want a full overview on everything from A-Z on how Phenibut works and all its benefits I highly recommend you check out this review that covers Phenibut in depth.


The Dosage of Phenibut should never exceed 500mg when you’re just starting out. After a while, you can move up to 1,000mg after you have more experience with it.

Side Effects

Phenibut should never be consumed more than twice every week. It’s easy to build up a tolerance to it rather quickly.

How to Take It

To take phenibut simply take a scoop of the powder and load it onto a digital scale you can get one for cheap here. To get an accurate dose put an empty glass on the scale and pour in 1/8th of a teaspoon of powder until it measures out to 500mg. After that fill the glass with water or juice and chug it down.

Where to Buy

If you’re interested in buying phenibut there are a few places online you can buy it from. The best place, however, I’ve found is science bio.

Everything on their site is third-party tested for complete purity.

They sell Phenibut and other nootropics as well, so if you really like nootropics I highly recommend you check them out, you can get 10% off when you use the discount code “harrisondeal10”.

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best nootropics for anxiety and depression

Ashwagandha is a root native to India and its use dates as far back as 6,000 years ago. It’s been used for millennia for its adaptogenic and medical properties. Today you buy ashwagandha in almost any store you walk into making it one of the cheapest but effective nootropics for dealing with anxiety.


You’re probably wondering how a plant has medicinal properties and how it can help with anxiety. The benefits of this plant lie in the root. The roots of ashwagandha contain phytonutrients that strengthen the plant and give it extra nutrients.

However, when it’s consumed by people the nutrients in ashwagandha works to bring down stress levels by reducing cortisol in the brain. These lead to a host of other benefits such as:

  • Relaxed demeanor
  • Significant decrease in anxiety
  • Higher testosterone
  • Improved Mood
  • Increases Life span

Those are impressive for just one little plant, you’re relaxed the whole day and less anxious about the little things that usually bother you.

Today I always keep this nootropic on hand it’s best taken when you first get up before you eat anything so you get the benefits throughout the day.


An effective dose is usually between 2,000-3,000mg a day.

Side Effects

There’s really not a lot of side effects from taking too much ashwagandha other than

  • Upset stomach
  • Nausea

The only other thing to make sure of is that if you take any medications consult your doctor before taking any supplement.

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L-Theanine is the amino acid found in green tea that produces a soothing effect alleviating stress and improves mood. If you find yourself anxious you can take this natural chill pill and your anxiety completely disappears.

This is another compound that plays on the brain’s GABA receptors, this helps the brain reduce neuron activity meaning if your mind is overactive and prone to anxiety L-theanine helps slow your brain activity.

This creates a calming effect that promotes relaxation and keeps you from feeling worried all the time.


L-Theanine boasts quite a few health benefits other than just reducing anxiety. It’s actually used to treat a wide variety of problems.

These include:

  • Decreasing Anxiety and Depression
  • Helps Improve sleep quality
  • Improves cognition
  • Improves attention span
  • Can help with dependency on substances


The recommended dose for L-theanine is between 100-200mg. That’s really all you need but some people who take it regularly take more.

Side Effects

Using L-theanine isn’t harmful as long as you stay within the recommended dose. Some side effects of taking to much L-theanine can include

  • Nausea
  • Upset stomach
  • Irritability

As always consult your doctor if you are taking prescription meds if it’s safe to take any supplement in tandem with prescription medication.

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If read through this site, you know I’m a huge fan of kratom and all the benefits that come with it. In terms of treating anxiety, kratom takes the cake, it’s impossible not to feel happy when you’re on kratom.

The first time I took It I thought “This stuff tastes gross” as I chugged down a glass of kratom water. Then about 30 minutes later I felt a rush of energy and euphoria run through me.

“Wow, this stuff really works,” I thought. The rest of the day I was in the best mood I’d ever been in.

Kratom: How it Works

Kratom is a plant that contains alkaloids that bind with the neurotransmitters in your brain that increase the production of chemicals like serotonin, dopamine, and adenosine.

So if you feel anxious then you might be low in these brain chemicals, using kratom can give a huge boost in these brain chemicals and have you feeling like a million bucks.


Kratom is great for anxiety but has many benefits in addition to that. Kratom is such a versatile plant it helps with all of the following:

  • Decreases anxiety
  • You feel way Happier
  • Can help with chronic pain
  • Potent energy rush
  • Way more motivated
  • Helps libido
  • Productivity drug

Honestly, there’s not a lot of things kratom can’t help with. If you’re having trouble with any of the above, definitely consider trying kratom.


You might have to play around with what the right kratom does is for you. You can start with half a spoonful and work your way up.

If you’re new to kratom here’s a general guideline to dosing:

  • 1-2 grams (Beginner)
  • 2-5 grams (Intermediate)
  • 5-9 grams (Advanced)

Remember to take kratom on an empty stomach so you’ll get the full effects of the plant more quickly. Also stay hydrated as kratom can have a dehydrating effect.

Side Effects

It’s easy to build up a tolerance to kratom pretty quickly so it’s important for you to rotate strains to avoid this. It’s best to buy a few strains at once if you take it regularly.

Other side effects of taking too much kratom include:

  • Nausea/vomiting
  • Lethargy/sleepiness
  • Brain Fog [R]
  • Dizziness

Most people experience a few symptoms if they take too much so just keep in mind to space out your dosing and stay hydrated when taking kratom.

Where to Buy

There’s plenty of kratom vendor you can buy from online if you’re into kratom or have never tried it before I recommend Golden Monk Kratom.

These guys have been around for years and they’re established as a solid company and have some of the highest quality kratom you can buy. Their kratom products are also affordable so you can stock up without breaking the bank.

I’ve bought their stuff for a long time and I’ve never been disappointed once. If you’re interested you can check them out below.

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5-HTP helps depression

5-HTP is a compound naturally produced by the body that is a precursor to the production of serotonin in the brain. Most people who have problems with depression have low serotonin levels so supplementing with 5-HTP can help level things out.

NOTE: Never take 5-HTP if you’re taking any anti-depressants or SSRIs. I include it here because it can help with feelings of depression. Combining SSRIs or any other anti-depressant with 5-HTP can potentially be hazardous or even deadly. SO PLEASE USE WITH CAUTION.


Supplementing with 5-HTP boosts serotonin production in the brain meaning you get the benefits of balancing out the happy chemicals in your brain that make you motivated and well adjusted.

A lot of health problems arise when you’re deficient in serotonin such as insomnia, being more prone to anxiety and depression, more fatigued, less motivated, and a general feeling of discontent.

If you experience these often it might be worth your while to supplement with 5-HTP until you figure out how to get your brain chemicals back in balance.

Some of the benefits that come with using 5-HTP include:

  • Helps alleviate depression/anxiety
  • Improves sleep quality
  • More energy


For most people, 300-500mg is all you need for an effective dose.

Side Effects

As I said above 5-HTP should not be taken if you take SSRIs for depression.

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Vitamins for Anxiety

Related to Nootropics, anxiety, and depression are caused by a deficiency in certain vitamins and minerals that are crucial for healthy brain function.

Being deficient in certain vitamins causes fatigue and brain fog that keeps your brain from functioning as it should. Just supplementing with a few basic vitamins will DRASTICALLY improve your energy levels and subsequently your mood.

Vitamin B Complex

Vitamin B is a crucial mineral for your brain and body to function properly. A lot of people deficient in vitamin B experience mood swings and fatigue on a daily basis.

Supplementing with a high-quality vitamin B super complex gives the body all the B vitamins needed to function properly and makes you more energetic and motivated to breeze through your day.

Supplementing with vitamin B has a host of benefits such as:

  • Improves Cognitive function
  • Decreases Feelings of Depression
  • Improves sleep quality
  • Works as an anti-aging supplement
  • Helps fight free radicals in the blood
  • Helps the production of sex hormones
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Vitamin D3

Vitamin D is an important vitamin your body literally couldn’t function without it. Vitamin D is produced by your body whenever it’s exposed to sunlight, anyone who lives in a place where there’s not a lot of sun, or if they stay inside all day is deficient in this major vitamin.

Even if you do live someplace where it’s always sunny, you’re still probably deficient in this crucial building block for healthy brain function. If this is you I recommend stocking up on some high-quality vitamin D3 tabs trust me you’ll feel like a million bucks.

Supplementing with vitamin D3 benefits include:

  • Aids in the balancing of hormones
  • Help decrease feelings of depression
  • Increase bone strength/density
  • Controls certain cancers

If you’re having any problems with regulating your mood or are chronically fatigued these are factors that contribute to ongoing depression and supplementing with these supplements in addition to the nootropics mentioned above will have a major impact on conquering your depression.

Once I started taking these vitamins with nootropics I felt like a new person, with more energy and feeling of overall content.

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Wrapping Up

With all the nootropics and vitamins listed above, you should have no problem crushing your anxiety for good. I’ve been using these supplements for years and it’s insane how much they’ve helped I wouldn’t be the same if I never found out about these supplements.

I hope these help you get rid of your anxiety and give you a healthier brain and body.

If the article helped you at all or if you have any questions leave them below and keep an eye out for future articles. Thanks and see you on the next one.

About the author 

Harrison Deal

My name is Harrison Deal, after trying several different nootropics I created this website as a way to give back to the community by creating a resource for information on nootropics, kratom, CBD, and different hacks for improving your health.

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